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Cholera is the leading cause of death in children in developing countries, characterized by massive diarrhea. The effects stem from an extracellular toxin that the bacterium Vibrio cholerae releases into the gut. The toxin acts on a _ that overstimulates which causes a cascade of events that leads to electrolytes leaving the cell and causing water to follow them into the lumen of the intestine, resulting in severe diarrhea.


A) protein- P : GTP
B) G proteins : adenylate cyclase
C) protein kinases : calmodulin
D) cAMP : G proteins
E) calcium : muscles

F) B) and C)
G) A) and E)

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All catecholamine- secreting cells synthesize dopamine.

A) True
B) False

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Direct communication between cells in contact with one another is accomplished through


A) paracrine chemical messengers.
B) endocrine hormones.
C) gap junctions.
D) receptors.
E) ligands.

F) None of the above
G) All of the above

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The chemical messenger of the nervous system is and chemical messenger of the endocrine system is .


A) hormone : neurotransmitter
B) neurotransmitter : hormone
C) autocrines : paracrines
D) neurohormone : adrenocorticoid
E) neurotransmitter : neurohormone

F) A) and B)
G) None of the above

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Steroid hormones are derived from the hormone testosterone.

A) True
B) False

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Which of the following statements is true for the nervous system but NOT the endocrine system?


A) A messenger is transported in the bloodstream.
B) Effector organs are scattered throughout the body.
C) There is a special anatomical arrangement between the secretory cell and the target cell.
D) Communication occurs over long distances.
E) A messenger communicates to target cells by binding to specific receptors.

F) A) and E)
G) C) and D)

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Tyrosine is one of four amino acids that function directly as chemical messengers.

A) True
B) False

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When the alpha subunit of the G protein is activated, it can stimulate ion channels to do what?


A) open only
B) either open or close
C) degrade
D) close only
E) alter the ion that travels through the channel

F) A) and E)
G) B) and D)

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Which of the following will NOT affect the magnitude of a cell's response to a specific hydrophilic ligand?


A) lipid solubility of the ligand
B) receptor upregulation
C) ligand concentration
D) number of receptors
E) affinity of the receptor for the ligand

F) B) and D)
G) A) and B)

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Which of the following enzymes catalyzes phosphorylation of a protein?


A) adenylate cyclase
B) tyrosine kinase
C) phosphodiesterase
D) phospholipase A2
E) tyrosine fi- hydroxylase

F) A) and B)
G) A) and C)

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A half- life, in terms of a chemical messenger, refers to


A) the radioactivity of the chemical messenger.
B) how long the chemical messenger will be effective in the body.
C) the time it takes for half of the chemical messenger in the blood to be degraded.
D) the amount of time it takes to cross the plasma membrane.
E) the amount of time the messenger is bound to a protein.

F) A) and C)
G) All of the above

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Catecholamines, such as dopamine, norepinephrine, and epinephrine, are derived from the amino acid


A) leucine.
B) glycine.
C) isoleucine.
D) tyrosine.
E) glutamate.

F) B) and D)
G) A) and C)

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Androgens are precursor molecules for the synthesis of


A) cortisol.
B) cholesterol.
C) progesterone.
D) estradiol.
E) aldosterone.

F) A) and D)
G) C) and D)

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Functionally, G proteins are classified into what three types?


A) alpha, beta, and gamma
B) slow, fast, and opened or closed
C) those that affect ion channels, stimulatory G proteins, and inhibitory G proteins
D) first, second, and third messengers
E) those that affect proteins, those that affect enzymes, and those that affect specific genes

F) A) and E)
G) A) and C)

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Aspirin decreases inflammation by inhibiting the actions of what enzyme?


A) cyclooxygenase
B) phospholipase A2
C) protein kinase A
D) lipoxygenase
E) dopa decarboxylase

F) C) and D)
G) B) and C)

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Aspirin is a nonsteroidal anti- inflammatory drug (NSAID) that relieves pain. Which mechanism best describes how NSAIDs work?


A) When aspirin dissolves in the interstitial fluid it causes a concentration gradient and fluid is pulled from the cell reducing inflammation.
B) Aspirin decreases the production of thromboxane A2, a chemical involved in blot clot formation, and COX inhibits A2 and, therefore, blood clots do not form and cause pain.
C) The COX receptors have a greater affinity for aspirin and these speed up the reactions of healing.
D) Prostaglandins (PG) are eicosanoids that produce pain and inflammation. Cyclooxygenase (COX) is an essential enzyme in the production of PG and aspirin inhibits COX and therefore relieves pain due to the reduced production of PG.
E) Leukotrienes are eicosanoids that produce pain and inflammation. COX is used in the lipoxygenase pathway and therefore NSAIDs stop the conversion of arachidonic acid to leukotrienes thereby reducing inflammation.

F) All of the above
G) A) and D)

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The target cells of the nervous system are


A) glial cells.
B) other neurons.
C) all the cell types in the body.
D) muscle cells.
E) neurons, muscles, or glands.

F) A) and B)
G) A) and C)

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Thyroid hormones alter the transcription of mRNA in the target cell.

A) True
B) False

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An amplifier enzyme catalyzes the synthesis of a second messenger.

A) True
B) False

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Describe the factors that affect the magnitude of a target cell's response. Assume that there is a receptor on the cell for the ligand.

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The first factor that affects a target c...

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