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Receptors for most water-soluble hormones are located


A) in the cytoplasm of their target cells.
B) on the plasma membrane of their target cells.
C) in the lysosomes of their target cells.
D) on the nuclear membrane of their target cells.
E) on the endoplasmic reticulum of their target cells.

F) C) and D)
G) A) and E)

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Increasing levels of thyroid hormones decrease TSH levels. This is an example of _______ feedback.

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Receptors for most lipid-soluble hormones are located


A) in the cytoplasm of their target cells.
B) on the plasma membrane of their target cells.
C) in the lysosomes of their target cells.
D) on the nuclear membrane of their target cells.
E) in the nucleus or cytoplasm of their target cells.

F) A) and E)
G) C) and D)

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Which of the following occurs when a hormone binds to a nuclear receptor?


A) activation of cyclic AMP
B) activation of mRNA synthesis
C) increased lipid synthesis by ribosomes
D) opens membrane channels
E) alters membrane permeability

F) C) and E)
G) B) and D)

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Given the following list of organic molecules, which includes hormones? 1) nucleic acid derivatives 2) polypeptides 3) steroids 4) proteins


A) 1, 3, 4
B) 1, 2, 3
C) 2, 3, 4
D) 1, 2, 3, 4
E) 1, 2, 4

F) A) and E)
G) C) and D)

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When a few intracellular mediator molecules activate several enzymes, and each of these activated enzymes activate still other enzymes, the hormone has initiated


A) a cascade effect.
B) a double loop effect.
C) a protein kinase effect.
D) a cyclic effect.
E) a negative feedback cycle.

F) D) and E)
G) C) and D)

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How do most water-soluble hormones travel in the bloodstream?


A) attached to proteins
B) attached to carbohydrates
C) attached to amino acids
D) as free hormones

E) A) and B)
F) A) and C)

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Hormone receptor molecules may be ____ in order to change the target cell's sensitivity to a given hormone.


A) increased in number
B) decreased in number
C) chemically altered
D) moved
E) increased in number, decreased in number and chemically altered

F) All of the above
G) B) and C)

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When a hormone binds to a membrane-bound receptor and activates G proteins,


A) ion channels could be opened.
B) IP3 may be activated.
C) cyclic AMP production may be increased.
D) DAG may be activated.
E) All of the choices may occur from activated G proteins.

F) A) and B)
G) B) and E)

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Which pattern of hormone secretion, exemplified by thyroid hormones, remains relatively constant over long periods of time?


A) acute hormone secretion
B) episodic hormone secretion
C) chronic hormone secretion
D) long-term hormone secretion

E) B) and C)
F) All of the above

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Which chemical class of hormone is more likely to need a binding protein for transport in the blood?


A) water-soluble
B) amino acid derivative
C) protein
D) lipid-soluble

E) C) and D)
F) A) and B)

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Match the description with the type of receptor model. -membrane channels may be opened or closed


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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Hormonal secretion can be regulated by


A) the action of a substance other than a hormone.
B) the nervous system.
C) other hormones.
D) All of these choices are correct.
E) None of these choices is correct.

F) D) and E)
G) A) and B)

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A chemical produced in a cell that activates specific processes in response to a hormone interaction with a membrane-bound receptor is referred to as a(n) _____.


A) hormone response element
B) transcription factor
C) messenger RNA
D) intracellular mediator

E) None of the above
F) C) and D)

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Predict which hormone would produce longer lasting effects:


A) Hormone A, which activates a G protein.
B) Hormone B, which binds to a nuclear receptor.
C) Hormone C, which stimulates the formation of a second messenger.
D) Hormone D, which activates adenylate cyclase.

E) A) and D)
F) B) and C)

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Match the description with the type of receptor model. -receptor molecule interacts with DNA


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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_______ chemical signals are released by cells and affect other cell types locally without being transported in blood.

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In ______, a cell increases the number of hormone receptors and becomes more sensitive to the hormone.


A) amplification
B) positive feedback
C) down-regulation
D) up-regulation

E) B) and D)
F) A) and D)

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Cortisol, a lipid-soluble hormone is released into the blood. Predict what cortisol might do.


A) can dissolve in the blood as free hormone
B) needs fenestrated capillaries to move out of the blood stream
C) readily diffuses through capillary wall
D) rapidly degraded by proteases in the bloodstream
E) may have carbohydrates attached to give a longer half-life

F) A) and B)
G) A) and C)

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What type of chemical messenger will act locally on nearby cells?


A) paracrine
B) neurotransmitter
C) autocrine
D) endocrine

E) C) and D)
F) A) and B)

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